PubMedhttps://pubmed.ncbi.nlm.nih.gov/37285902Comprehensive Analysis of Hemophilia A (CAHEA): Towards …Background: Hemophilia A (HA) is the most frequently occurring X-linked bleeding disorder caused by heterogeneous variants in the F8 gene, one of the largest genes known. Conventional molecular analysis of F8 requires a combination of assays, usually including long-range polymerase chain reaction (LR-PCR) or inverse-PCR for inversions, Sanger sequencing or …

Naturehttps://www.nature.com/articles/s41569-024-01050-w.pdf[PDF]Characterization of the F8 gene: a silver lining in a dark …2024年9月12日 · Sequencing of the F8 gene was the initial step in developing replacement therapy with recombinant FVIII, and thereby removing the risk of blood-borne infections. After gene homology analysis ...